The Historical Development of Animal Toxicity Testing

Promoting the 3Rs to enhance the OECD fish toxicity testing framework.

Fish toxicity testing has been conducted since the 1860's in order to help define safe levels of chemical contaminants in lakes, rivers and coastal waters. The historical emphasis on acute lethality testing of chemicals has more recently focussed on long term sublethal effects of chemicals on fish and their prey species. Fish toxicity testing is now embedded in much environment legislation on c...

Critical evaluation of current developmental toxicity testing strategies: a case of babies and their bathwater.

This review is the second in a series of four papers emanating from a workshop entitled "Developmental Toxicology-New Directions," which was sponsored by the ILSI Health and Environmental Sciences Institute's (HESI) Developmental and Reproductive Toxicology Technical Committee. The present review analyzes the strengths and weaknesses of current developmental safety testing approaches in an effo...

Short-term safety and risk evaluation of engine oil enriched by high concentrations copper nanoparticles on the skin

Abstract Objective(s): Copper nano particles are added to ordinary engine oil as an additive to reduce friction and repair damaged surface under friction conditions. However, it is still unclear what environmental effects such a compound might have on conventional engine oils and its toxicity in different animal species has not been determined. The aim of this study is to investigate the ...

مروری بر روشهای ارزیابی سمیت مواد شیمیایی، گذار از روشهای اینویوو به روشهای نوین اینویترو

Exposure to occupational and environmental contaminants is a major contributor to human health problems. Despite significant achievements in the risk assessment of chemicals, the toxicological database, particularly for industrial chemicals, remains limited. Considering there areapproximately 80, 000 chemicals in commerce, and an extremely large number of chemical mixtures, in vivo testing of t...

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN